Journal article
Risks of colorectal and other cancers after endometrial cancer for women with lynch syndrome
AK Win, NM Lindor, I Winship, KM Tucker, DD Buchanan, JP Young, C Rosty, B Leggett, GG Giles, J Goldblatt, FA MacRae, S Parry, MF Kalady, JA Baron, DJ Ahnen, LL Marchand, S Gallinger, RW Haile, PA Newcomb, JL Hopper Show all
Journal of the National Cancer Institute | OXFORD UNIV PRESS INC | Published : 2013
DOI: 10.1093/jnci/djs525
Abstract
Background Lynch syndrome is an autosomal dominantly inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Previous studies have shown that MMR gene mutation carriers are at increased risk of colorectal, endometrial, and several other cancers following an initial diagnosis of colorectal cancer. We estimated cancer risks following an endometrial cancer diagnosis for women carrying MMR gene mutations. Methods We obtained data from the Colon Cancer Family Registry for a cohort of 127 women who had a diagnosis of endometrial cancer and who carried a mutation in one of four MMR genes (30 carried a mutation in MLH1, 72 in MSH2, 22 in MSH6, and 3 in PMS2). We used the ..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the National Cancer Institute, National Institutes of Health under RFA CA-95-011, and through cooperative agreements with members of the Colon Cancer Family Registry and principal investigators. AKW is supported by the Picchi Brothers Foundation Cancer Council Victoria Cancer Research Scholarship, Australia. JLH is a National Health and Medical Research Council Australia Fellow. MAJ is a National Health and Medical Research Council Senior Research Fellow. JPY is a Cancer Council Queensland Senior Research Fellow. CR is a Jass Pathology Fellow.